| 1. | A study to identify genes associated with abnormal naevi (by implication therefore, melanoma susceptibility genes) and cutaneous ageing.
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| 2. | Diabetes. Obesity, intrauterine growth and atherosclerosis: the fetal origins hypotheses.
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| 3. | Inadequate sperm: a molecular biological investigation of the commonest endocrine disorder.
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| 4. | Genetic and molecular investigation of ischaemic heart disease using family based studies.
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| 5. | Identification of the genetic predisposition to diabetic nephropathy.
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| 6. | A genome wide search for susceptibility genes for nephropathy and albuminuria employing novel studies in type two diabetes.
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| 7. | Mapping of genetic susceptibility for insulin-dependent (type 1) diabetes mellitus in the Northern Ireland population.
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| 8. | The study of inherited ophthalmic disorders.
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| 9. | Studies of inherited breast cancer and fragile X.
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| 10. | Studies of familial hypocholestemia.
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| 11. | Studies on tylosis, familial colonic polyps and colorectal cancer and Peutz-Jaeger syndrome.
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| 12. | Identification of genes relevant to the early detection of pancreatic cancer.
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| 13. | Investigation of genetic risk factors for lung cancer.
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| 14. | Concerted action on polyposis coli.
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| 15. | Clinical diagnosis of hereditary non-polyposis colon cancer: managing perceived risk.
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| 16. | Isolation and characterisation of candidate tylosis oesophageal cancer genes.
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| 17. | A randomised controlled trial of colorectal polyp and cancer prevention using aspirin and resistant starch in carriers of hereditary non-polyposis colon cancer (CAPP-2).
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| 18. | Establishment of a European registry for hereditary pancreatitis and familial pancreatic cancer.
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| 19. | The molecular pathogenesis of hereditary pancreatitis and familial pancreatic cancer.
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| 20. | Identification of new genes responsible for pancreatic cancer.
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| 21. | Metastasis genes in prostate cancer.
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| 22. | Chromosome re-duplication in cervical neoplasia.
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| 23. | Numerical chromosome aberrations and tumour ploidy in ovarian neoplasia.
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| 24. | The role of human papillomavirus infection in the development of vulval neoplasia.
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| 25. | The role of human papillomavirus infection in the development of cervical glandular neoplasia.
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| 26. | Novel metastasis-suppressing genes in human prostate cancer.
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| 27. | Cleft lip palate linkage project.
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| 28. | Genetic pathology of bronchial epithelium in tumour-bearing lungs and the relationship to metaplasia and dysplasia.
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| 29. | An investigation into the role of DNA repair genes and telomerase activity in non-small cell lung carcinomas.
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| 30. | Early molecular events in the pathogenesis of lung cancer.
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| 31. | The role of transposable elements in the pathogenesis of lung cancer.
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| 32. | Molecular pathogenesis of lung cancer.
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| 33. | Isolation and characterisation of tylosis oesophageal cancer genes.
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| 34. | Further characterisation of the physical map of the region of chromosome 17q25 containing the tylosis.
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| 35. | Oesophageal cancer (TOC) genes and identification of additional candidate TOC genes.
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| 36. | Molecular diagnosis of dysplastic lesions and oral cancer.
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| 37. | Natural history of transfusion-acquired HCV infection: identification of host and viral genetic predictors of clinical outcome.
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| 38. | National molecular genetics register of familial pancreatic cancer.
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| 39. | Prognostic value of tumour DNA in serum in oral cancer.
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| 40. | Genetic risk factors for alcoholic liver disease.
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| 41. | Mutation studies in propionic acidaemia and methylmalonic aciduria.
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| 42. | Environmental and genetic predisposing factors for chronic disease and cancer (EPIC study).
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| 43. | Ely study of type 2 diabetes.
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| 44. | Investigation of the prevalence of germline mutations in BRCA1 and BRCA2 in women with breast cancer diagnosed before 30 years of age or with a strong family history.
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| 45. | A population based study of familial breast cancer in East Anglia.
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| 46. | Evaluating services for women with familial risk of breast cancer; consumer push or practitioner pull in primary care consultations.
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| 47. | An assessment of screening for fragile X syndrome.
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| 48. | Screening for cystic fibrosis.
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| 49. | Evaluation of molecular pre-natal diagnosis for Down's syndrome.
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| 50. | Genetic services in pregnancy—an evaluation of the genetic family register approach.
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| 51. | Detection of fetal abnormality at different gestations: impact on parents and service implications.
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| 52. | A randomised controlled trial of the effect of a practice-based genetic screening facilitator.
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| 53. | Genetic influences on intra-uterine growth and their relationship to non insulin-dependent diabetes and vascular disease.
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| 54. | Evaluation of genetic profiling for predicting bone marrow transplant.
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| 55. | Development and clinical application of a test to detect cryptic cytogenetic abnormalities in patients with idiopathic retardation.
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| 56. | Predictive genotyping for platelet transfusion resistance in multi-transfused patients.
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| 57. | Identifying the contribution of micro-environmental and genetic influences to osteolysis around joint replacements.
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| 58. | The molecular genetics of non insulin-dependent diabetes (NIDDM) and its relationship with intra-uterine development.
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| 59. | Use of biomarkers in classifying, treating and preventing the secondary progression of osteoarthritis.
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| 60. | National Case Registration of pre- and post-natal cytogenetic diagnosis of chromosomal anomalies causing Down's Syndrome (NDSCR).
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| 61. | The chromosome abnormality database.
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| 62. | Development and optimisation of methods to detect germline mutations and microsatellite instability in HNPCC families; and finding new colon cancer genes in non-HNPCC families.
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| 63. | Epidemiological study of BRCA1 and BRCA2 carriers.
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| 64. | UKCCCR national familial ovarian cancer screening study.
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| 65. | Risk of testis cancer in the families of patients with bilateral testicular germ-cell malignancy.
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