APPENDIX 45
Letter from Don Aston to the Chairman
of the Committee (PC 66)
As you will no doubt be aware The Royal College
of Physiciansuniquely well-placed to know at least so far
as hospital deaths are concernedstated in their response
dated 23/7/03 to the original Joffe Assisted Dying Bill that "there
is no doubt whatsoever that many (dying) patients suffer appallingly,
and that death for many people is protracted, undignified and
agonising" (para 5.2). Obviously only the present tiny minority
are ever likely to die as hospice inpatients but an enormous improvement
could easily be brought about if the dying wherever they are being
cared for had access to hospice levels of opioid pain relief (and
sedation) particularly in the very final stages of their lives.
A major reason for this is the lack of any consensus
in the sources of guidance to doctors (and soon nurses) prescribing
opioids in terminal care. You may think unbelievably for the last
7 years the British Medical Association (BMA) has published two
such incompatible guides simultaneouslythe British National
Formulary (BNF) and the British Medical Journal's hospice-influenced
ABC of palliative care (please see the attached for these and
other examples). You will not need me to tell you that unfortunately
heroin-type drugs are indiscriminately demonised in anti "recreational"
drugs campaigning when it might have been thought it would be
easy to differentiate between the drug class (arguably the most
important in medicine) and inappropriate use. The problem is further
compounded by the uniquely wide prescribing range in palliative
care (at least according to hospice sources)at least 1,000
times. Local hospital protocols (eg Gosport War Memorial Hospital
subject to an ongoing investigation for the last 7 years) are
often even more restrictive than nationally published guidelines.
In addition terminal sedation (patients being made unconscious
until they die with hydration withdrawn) is far more commonand
at patients' request and sometimes for many days ) is far more
likely to be available in hospices than elsewhere because an alternative
description of the practice is "slow euthanasia". Shamefully
since the Shipman case (as also in the almost two years leading
up to the murder trial of the Newcastle GP, the late Dr J D Moor)
there is evidence that some doctors became even more reluctant
to prescribe adequate opioids for dying patients than they already
were previously. But no far as I am aware no hospice doctor has
ever been tried for murder, or been suspended and investigated
sometimes for years, or been found to have no case to answer but
whose employers refuse to reinstate them even though their accusers
remain in post for alleged "inappropriate" opioid prescribing
in terminal care. Mainstream doctors have not been so fortunate
and details of specific cases can be supplied if required
SOURCES OF GUIDANCE AVAILABLE TO DOCTORS
ON THE USE OF OPIOIDS IN TERMINAL CARE
|
| Incompatibilities between sources relate to:
| |
|
| Indicative dose ranges (please see below)
Proportion of patients said to be likely to require high doses (please see below)
Acceptable rate of dose increase when required Treatment of opioid toxicity
|
| Ambiguities relate to: | Assumed administration route ie oral or parenteral.
(in some sources) Particular opioid to which the indicative dose range relates
|
| Source | Indicative Dose Range (Assumed to be Oral Morphine Equivalent per 24 hours)
|
British National Formulary No 32
(to March 97)
| 30 to 900mg |
British National Formulary No 33
(from March 97)
| 30 to 3, 000mg |
| MIMS | No upper limit "Contrary to popular misconception, there is no maximum dose for morphine in [severe pain]"
|
| Typical Hospice (eg Palliative Care Handbook Open University K260)
| 15 to 15, 000mg (assumed smooth progression over dose range)
|
British Medical Journal Sept 97
(ABC of palliative care)
| 30 to 15,000mg ("very few need high dosesmost require less than 200mg a day")
|
Palliative Care Formulary 1
Twycross etc
| One-third of patients need in excess of 200mg and up to 1, 200mg
|
| Oxford Textbook of Palliative Medicine |
15 to 15, 000mg ("whilst most patients require 200mg/day or less some need much higher doses")
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| Oxford Textbook of Oncology Vol 2 | 30-40% of patients will require more than 200mg
|
| Cancer Pain ManagementMcGuire etc & Textbook of Pain 3rd Ed Wall & Melzack
| 400-600mg average
Requirement10%
Require more than 2,000mg
Intramuscularly citing Coyle et al
(1990) Journal of Pain Management
|
|
HOSPICE PALLIATIVE
CONSULTANTS ON
OPIOID OVERDOSES
"Even with accidental overdose 5-10 times the routine
dose, the patient is only likely to become drowsy for a few hours
and then recover spontaneously." Dr Kilian Dunphy "There
is abundant evidence of people having been given inadvertently
20, 30 and even on one occasion 100 times what had been prescribed.
Whilst it can be a tragic error, the patient may wake up 4 hours
later to say it is the best sleep he has had for some time . .
. there is no danger in these drugs." Dr Derek Doyle.
13 May 2004
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