Supplementary Memorandum
submitted by the Rowett Institute following the evidence session
of 10 March 1999
The evidence that ConA transgenic potatoes were
the prime interest of Dr Pusztai in his discussions with World
in Action and the media prior to the Rowett's discovery of
this unpublished data in the public domain is overwhelming.
1. The World in Action press release
sent out well before the broadcast, ie during or before the weekend
of 8-9 August, states: "Scientists have discovered that rats
fed genetically modified potatoes suffered stunted growth and
damage to the immune system after a 100 days".
NOTE: Dr Pusztai
only had data of stunted growth in his ConA (Jackbean) studies.
The GNA (snowdrop) studies showed no stunted growth as he re-emphasised
to Prof James and Dr Chesson on the morning of 10 August. In terms
of immune results, there were none on genetically modified potatoes
fed for 110 days at the time of the broadcast, let alone when
filming took place in June. The only data available were on ConA
treated potatoes and these turned out to be the spiked, not the
transgenic potatoes. Only late on 11 August was this revealed
by Dr Pusztai's assistant. The Rowett had no knowledge of the
ConA studies until the morning of 10 August, nor any media contact
relating to GMOs until the afternoon of 10 August.
2. National newspapers quoted evidence on
ConA or the Jackbean in their editions available on the morning
of 10 August. Thus The Express newspaper's environmental
correspondent John Ingham states: "British scientists showed
for the first time that a crop given the genes of another species
could cause health problems in animals which ate it".
"They found that rats fed potatoes given
a bean gene suffered from slightly stunted growth and were likely
to be more vulnerable to disease. The expert who led the governement
funded research claimed that the British public were being treated
like `guinea pigs' in the rush to bring GM foods on to the market."
"`Professor Pusztai fed rats for 110 days
on potatoes given a bean gene to make it resistant to insects.
He said: `these potatoes are designed to affect insects, so we
wanted to know what impact they would have on higher mammals'."
"`The effect was slight growth reductions
and an effect on the immune system. We do not know whether it
was temporary or irreversible.'"
NOTE: In this
Express article quotations are used for text which was
not in the World in Action press release so presumably
came from the personal discussions between Dr Pusztai and The
Express newspaper as stated by Dr Pusztai. Only ConA transgenic
experiments are discussed in relation to GM foods with no mention
of GNA transgenics.
3. The Times on the morning of 10
August contained an article by Nigel Hawkes entitled "Gene
potatoes damage rats' immune systems". The article specifies
"Professor Arpad Pusztai of the Rowett Research Institute"
as providing him with a series of quotes throughout the article.
The third paragraph has Nigel Hawkes' account of the studies as
follows: "the trials have been carried out on potatoes carrying
genes from both the snowdrop and the Jackbean. The genes are responsible
for producing proteins called lectins, which protect the parent
plants from aphid and nematode attack. Potatoes resistant to these
pests could be valuable."
"But lectins are known to damage immune-system
cells, so the feeding experiments with rats were designed to see
if the damage occured when the lectins were present in the potatoes.
In the case of the snowdrop lectin, no such effect was observed,
but the jackbean lectin did suppress the immune system."
Then Nigel Hawkes quotes as from Dr Pusztai
as follows: "`The feeding trial went on for 110 days, equivalent
to 10 years in human terms. The result' he said `emphasised the
need for proper trials of all modified crops.'"
"`If you start with the idea that a gene
isn't toxic, and just go through the motions, you won't find anything,'
he said. `But that isn't good enough. You have to really demonstrate
that there are no harmful effects. Our modified potatoes will
only be released after such tests have been completed, and I can
tell you that the one with jackbean in it will not be released
at all.'"
NOTE: Dr Pusztai
identifies the Jackbean-modified potato study as showing the toxic
effects and implies that there were other studies, presumably
with the snowdrop, referred to by Nigel Hawkes as the experiment
of lesser concern.
4. Reuters, London, 10 August. "Genetically
modified potatoes can damage the immune systems of rats, according
to British research released today that calls into question the
safety of the new food technology".
"Professor Arpad Pusztai of Aberdeen's
Rowett Institute said he had fed five rats on genetically modified
potatoes that carried genes from the snowdrop and jackbean for
110 daysequivalent to 10 years in human terms."
"His research showed that the rats suffered
from slightly stunted growth and were more likely to be vulnerable
to disease. It was thought to be the first time that trials of
genetically modified food had showed harmful effects."
NOTE: This release
may explain the global interest in the stunted growth and vulnerability
to disease (elsewhere related to the immune system) which was
the basis for all telephone calls from 9 am on Monday, 10 August
1998. All the telephone calls related to ConA (Jeackbean), presumably
because the immune data and stunted growth only applied to the
supposedly completed ConA transgenic data.
5. Evidence from the broadcast World
in Action programme itself on the evening of 10 August 1998.
The transcript specifies as follows:
"Andrew Brittain: `Rats have fed two different
kinds of genetically modified potatoes which are not on sale and
have never been eaten by humans. The rats ate them for more than
100 days, the human equivalent of 10 years'."
Later by Andrew Brittain: "animals fed
on one kind of research potato remained perfectly healthy. But
rats given the other set did show ill-effects. The Professor is
so concerned about the implications of his discovery, he's decided
to publicise his findings early. Tonight, he reveals them for
the first time".
Arpad Pusztai: "The effect was slight growth
retardation and an effect on the immune system. One of the genetically
modified potatoes, after 110 days, made the rats less responsive
to immune effects".
Note: On 10 August Dr Pusztai had no immune
results from any genetically modified potato experiments fed for
110 days. Professor James and Dr Chesson were told on Monday morning
10 August, by Dr Pusztai, to ignore the GNA studies since they
showed no effects. Professor Bremner, Deputy Director of the Rowett,
was also told on the afternoon of 10 August by Dr Susan Bardocz,
leader of the Pusztai team, when challenged as to whether spiked
or transgenic ConA studies had been conducted responded that they
had "looked at all combinations". It was the Rowett's
insistence on seeing all the data, particularly on GNA, which
led on Tuesday evening, 11 August, to the discovery that no transgenic
ConA studies had been conducted and that no immune studies were
available on 110-day-fed transgenic GNA potato experiments.
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